Indoor settled dust may result in significant human exposure to chemicals, especially by ingestion following hand-to-mouth contact. As other environmental media of exposure, dust may thus be subject to regulation. An international scientific workshop was convened in Paris in September 2019 to assess the relevance for public health of setting guidelines for indoor settled dust, and secondly to discuss scientific and technical challenges related to such guidelines. The main discussions and conclusions, with consensus achieved, are reported herein. They concern general considerations, objectives and definitions, relevance for a health-based guideline, unit, and finally computation. These points should be addressed when considering indoor dust guidelines as part of a policy to reduce exposure to a given chemical.